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  Nat Genet | 中美等多国研究团队完成超百万人跨祖先全基因组荟萃分析，鉴定新的肺癌易感位点

  Nature 子刊 | 全基因组 cfDNA 甲基化分析可实现小细胞肺癌的灵敏检测、预后监测及分子分型

  应用文献

  Patient-derived organoids for personalized gallbladder cancer modelling and drug screening

  Tumor-polarized GPX3+ AT2 Lung epithelial cells promote premetastatic niche formation

  Differentially Expressed Autophagy-Related Genes are Potential Biomarkers and Therapeutic Targets in Atrial Fibrillation

  Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells

  The Human Cytomegalovirus US31 Gene Predicts Favorable Survival and Regulates the Tumor Microenvironment in Gastric Cancer

  Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease

  MiR-520b inhibits endothelial activation by targeting NF-κB p65-VCAM1 axis

  Positive Feedback Loop of Long Noncoding RNA OASL-IT1 and Innate Immune Response Restricts the Replication of Zika Virus in Epithelial A549 Cells

  Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and transcriptional activities of ECs in CC

  A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells

  A plasma membrane transporter coordinates phosphate reallocation and grain filling in cereals

  Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis

  Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

  Cardiac ankyrin repeat protein contributes to dilated cardiomyopathy and heart failure

  ADP ribosylation factor guanylate kinase 1 promotes the malignant phenotype of gastric cancer by regulating focal adhesion kinase activation

  Reprogrammed mesenchymal stem cells derived from iPSCs promote bone repair in steroid-associated osteonecrosis of the femoral head

  The G4 resolvase RHAU modulates mRNA translation and stability to sustain postnatal heart function and regeneration

  A genome-wide survey of interaction between rice and Magnaporthe oryzae via microarray analysis

  Effect of pristimerin on apoptosis through activation of ROS/ endoplasmic reticulum (ER) stress-mediated noxa in colorectal cancer

  Grain‐sized moxibustion promotes NK cell antitumour immunity by inhibiting adrenergic signalling in non–small cell lung cancer

  Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis

  Dysregulation of autophagy-associated microRNAs in condyloma acuminatum

  Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Acute Myocardial Infarction

  Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses

  Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice

  The TetR-type regulator AtsR is involved in multidrug response in Corynebacterium glutamicum

  Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas

  LncRNA TNFRSF10A-AS1 promotes gastric cancer by directly binding to oncogenic MPZL1 and is associated with patient outcome

  FMRP ligand circZNF609 destabilizes RAC1 mRNA to reduce metastasis in acral melanoma and cutaneous melanoma

  The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease

  Fungal–Bacterial Networks in the Habitat of SongRong (Tricholoma matsutake) and Driving Factors of Their Distribution Rules

  Adipose Rheb deficiency promotes miR-182-5p expression via the cAMP/PPARγ signaling pathway

  Plasma circRNA microarray profiling identifies novel circRNA biomarkers for the diagnosis of ovarian cancer

  BAY-885, a mitogen-activated protein kinase kinase 5 inhibitor, induces apoptosis by regulating the endoplasmic reticulum stress/Mcl-1/Bim pathway in breast cancer cells

  Collagen scaffold loaded allogeneic neural stem cells promoted locomotion recovery of spinal cord injury mainly through secreting neurotrophic factors

  FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis

  Relationship between DNA Methylation Profiles and Active Tuberculosis Development from Latent Infection: a Pilot Study in Nested Case-Control Design | Microbiology Spectrum

  The Association between Circulating microRNAs and the Risk of Active Disease Development from Latent Tuberculosis Infection: a Nested Case-Control Study | Microbiology Spectrum

  Metabolites of gut microbiota fermenting Poria cocos polysaccharide alleviates chronic nonbacterial prostatitis in rats

  Deletion of Hnrnpk Gene Causes Infertility in Male Mice by Disrupting Spermatogenesis

  Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice

  Novel patient-derived xenograft and cell line models for therapeutic screening in NF2- associated schwannoma

  A Capsidless Virus Is trans-Encapsidated by a Bisegmented Botybirnavirus

  Two Novel Rhabdoviruses Related to Hypervirulence in a Phytopathogenic Fungus | Journal of Virology

  Six Novel Mycoviruses Containing Positive Single-Stranded RNA and Double-Stranded RNA Genomes Co-Infect a Single Strain of the Rhizoctonia solani AG-3 PT

  Anticancer effects of disulfiram in T-cell malignancies through NPL4-mediated ubiquitin–proteasome pathway

  The IL-21-TET2-AIM2-c-MAF pathway drives the T follicular helper cell response in lupus-like disease

  Integrative analysis of DNA methylation and gene expression reveals key molecular signatures in acute myocardial infarction

  Sequentially fermented dealcoholized apple juice intervenes fatty liver induced by high-fat diets via modulation of intestinal flora and gene pathways

  Small extracellular vesicles from iPSC-derived mesenchymal stem cells ameliorate tendinopathy pain by inhibiting mast cell activation

  Chenodeoxycholic acid inhibits lung adenocarcinoma progression via the integrin α5β1/FAK/p53 signaling pathway

  Fusarivirus accessory helicases present an evolutionary link for viruses infecting plants and fungi

  Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer

  EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription

  Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression

  Stemness Maintenance and Massproduction of Neural Stem Cells on Poly L-Lactic Acid Nanofibrous Membrane Based on Piezoelectriceffect

  Biosynthesis of rumbrins and inspiration for discovery of HIV inhibitors

  Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s Disease-like neurodegeneration by causing energy metabolism disorders in mice

  Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor

  NLRP3 inflammasome links vascular senescence to diabetic vascular lesions

  Overexpression of MET4 Leads to the Upregulation of Stress-Related Genes and Enhanced Sulfite Tolerance in Saccharomyces uvarum

  IL-35 enhances angiogenic effects of small extracellular vesicles in breast cancer

  Cell Division Cycle-Associated Genes Are Potential Immune Regulators in Nasopharyngeal Carcinoma

  Glycosyltransferase Extl1 Promotes CCR7-Mediated Dendritic Cell Migration to Balance Immunity and Tolerance

  Stemness Maintenance and Massproduction of Neural Stem Cells on Poly L-Lactic Acid Nanofibrous Membrane Based on Piezoelectriceffect

  A transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury

  A Novel Peptide Derived from Arca inflata Induces Apoptosis in Colorectal Cancer Cells through Mitochondria and the p38 MAPK Pathway

  Epigenetic changes in inflammatory genes and the protective effect of cooked rhubarb on pancreatic tissue of rats with chronic alcohol exposure

  Tumor-associated macrophages promote cholangiocarcinoma progression via exosomal Circ_0020256

  Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2-mediated autophagy

  Rocaglamide promotes the infiltration and antitumor immunity of NK cells by activating cGAS-STING signaling in non-small cell

  Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to para-Aminosalicylic Acid in Mycobacterium tuberculosis | Antimicrobial Agents and Chemotherapy

  Patient-derived organoids for personalized gallbladder cancer modelling and drug screening

  The role of polypeptide PDTLN1 in suppression of PI3K/AKT signaling causes cardiogenetic disorders in vitro and in vivo

  Reducing the Periplasmic Glutathione Content Makes Escherichia coli Resistant to Trimethoprim and Other Antimicrobial Drugs

  Prognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma

  Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms

  Clinical challenges of tissue preparation for spatial transcriptome

  Anatlas of dynamic peripheral blood mononuclear cell landscapes in human perioperativeanaesthesia/surgery

  Turning gray selenium into a nanoaccelerator of tissue regeneration by PEG modification

  Prenatal exposure to environmentally relevant levels of PBDE-99 leads totesticular dysgenesis with steroidogenesis disorders

  MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer

  MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene

  The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer

  Identification of New Tumor-Related Gene Mutations in Chinese Gastrointestinal Stromal Tumors

  Comprehensive Analysis of the Transcriptome-Wide m6A Methylation Modification Difference in Liver Fibrosis Mice by High-Throughput m6A Sequencing

  LncRNA-MIAT promotes thyroid cancer progression and function as ceRNA to target EZH2 by sponging miR-150-5p

  PHF5A promotes colorectal cancer progression by alternative splicing of TEAD2

  PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy

  SOCS2 Suppresses Inflammation and Apoptosis during NASH Progression through Limiting NF-κB Activation in Macrophages

  Discrete genetic loci in human gut Bacteroides thetaiotaomicron confer pectin metabolism

  Identification of New Tumor-Related Gene Mutations in Chinese Gastrointestinal Stromal Tumors

  CircNPHP4 in monocyte-derived small extracellular vesicles controls heterogeneous adhesion in coronary heart atherosclerotic disease

  iNKT subsets differ in their developmental and functional requirements on Foxo1

  Suppressed inflammation in obese children induced by a high-fiber diet is associated with the attenuation of gut microbial virulence factor genes

  Inherent hepatocytic heterogeneity determines expression and retention of edited F9 alleles post-AAV/CRISPR infusion

  Enhancing Ristomycin A Production by Overexpression of ParB-Like StrR Family Regulators Controlling the Biosynthesis Genes

  Using a new HSPC senescence model in vitro to explore the mechanism of cellular memory in aging HSPCs

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